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Dayvigo vs. Ambien


Women with insomnia

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Sleep issues can impact every aspect of our lives, leaving us depleted, irritable, and groggy each day we go without sufficient rest. 

When you’re dealing with insomnia, you want relief now and your body can’t wait. Skip the inconvenient commute and long wait times of traditional clinics and let Klarity’s providers diagnose your symptoms and help you find the treatment you need.

To consult with a medical provider about your sleep issues, take this brief 2-minute survey and Klarity will connect you with an insomnia specialist within 48 hours. 

Dayvigo and Ambien are medications from different drug classes that are often prescribed to treat insomnia. Let’s take a closer look at what each medication offers so that you can make informed decisions about your health to get the relief you need.

This article discusses suicide, suicidal ideation, and self-harm. If you or someone you know is experiencing suicidal thoughts or is in crisis, contact the Suicide Prevention Lifeline immediately at 800-273-8255. 

What is Dayvigo?

Dayvigo, also known as Lemborexant, is one of the prescription drugs that falls under the orexin receptor antagonist class of drugs. This medication is a controlled substance that blocks orexin, a neuropeptide that regulates arousal, wakefulness, and appetite. 

Dayvigo Forms and Doses

Dayvigo is a tablet taken orally once a day and is typically prescribed in doses of 5 mg, with a maximum dosage of 10 mg based on your healthcare provider’s recommendation. It’s best to take Dayvigo when you can get at least seven hours of sleep before having to wake up. 

Conditions Dayvigo Treats

Dayvigo is a prescription drug used to help those who are 18 and older who have issues with sleep maintenance and sleep efficiency like insomnia. 


Insomnia is a sleep disorder that can cause issues falling asleep, maintaining sleep, or going back to sleep after waking up earlier than anticipated. While it can impact your energy and mood the following day, insomnia can also negatively affect your health and job performance. Sleep aids are one form of treatment for alleviating symptoms of insomnia.

Dayvigo Costs

If you’re uninsured, the cost will depend on the current list price, around $300, and any pharmacy-related fees. If you have commercial insurance, most can expect to pay between $30 and $38 for a Dayvigo prescription. For those with Medicare Part D coverage, the average cost is about $27 per month, whereas those with Medicaid pay around $48.  

Dayvigo Side Effects

Dayvigo is considered one of the federally controlled substances and can have serious adverse effects like:

  • Sleep paralysis
  • Headaches
  • Worsening depression or suicidal ideation
  • Unusual sleep behaviors like sleep-walking or sexual activity that you don’t remember
  • Muscle weakness
  • Nightmares
  • Drowsiness

Dayvigo Warnings for Use

Before taking Dayvigo, it’s crucial that you tell your doctor about any medications, vitamins, or supplements that you’re taking. It may not be right for you if you have certain conditions or other factors that affect your health. 

Dayvigo is a controlled substance, which is why it’s so important that you take it exactly as your healthcare provider prescribes it. If you have issues with alcohol or substance misuse, your doctor may want to pursue a different option for treatment. You should not mix Dayvigo and alcohol, as it can increase the risk of negative side effects. 

You should also avoid taking Dayvigo if you have liver problems, narcolepsy, pulmonary issues, or are over 65 years old. 

Dayvigo Interactions

As always, you should consult your doctor before taking any new medication. Dayvigo has 404 known drug interactions, with 139 major interactions, 262 moderate, and three minor. Those can include:

  • Central nervous system depressants 
  • Certain blood pressure medications
  • Some antibiotics 
  • Antifungals or antimicrobial drugs
  • St. John’s Wort
  • Narcolepsy medications
  • Wellbutrin
  • Methadone
  • Carbamazepine
  • HIV antiviral medications

Dayvigo also has major interactions with alcohol and grapefruit juice, which can increase the risk of negative side effects like drowsiness, central nervous system depression, abnormal sleep behaviors, suicidal ideation, headaches, and changes in heart rate. 

Additionally, Dayvigo moderately interacts with nicotine, which can make the intended results of the medication less effective. 

Dayvigo also interacts with four diseases: 

  • alcoholism 
  • depression 
  • liver disease
  • compromised respiratory function 

What is Ambien?

Ambien, also called Zolpidem in its generic form, is a sedative or hypnotic used for treating insomnia. It’s a controlled substance that corrects chemical imbalances if you’re experiencing sleep issues to help you fall asleep.

Ambien Forms and Doses

Ambien comes in different forms, including a spray, immediate-release tablet, and extended-release tablet. Dosage varies from person to person, typically between 10-12.5 mg, so you should always take Ambien exactly as your doctor prescribes and never share your prescription with anyone else.

Conditions Ambien Treats

Ambien is prescribed to those 18 and older to treat sleep issues like insomnia. If you’re prescribed immediate-release tablets, this form of Ambien will help you fall asleep quickly. The extended-release tablets have an outer layer that dissolves first, allowing you to fall asleep, and then another layer that dissolves over time, which helps you stay asleep.  


If you experience insomnia, you have difficulty sleeping. That could mean it’s hard for you to fall asleep, stay asleep, or go back to sleep if you’ve woken up before you’re ready to be active. Insomnia can be extremely frustrating, as it can leave you feeling drained and moody and negatively impact other areas of your life. 

Ambien Costs

Most insurance plans, including Medicare, cover the generic version of Ambien, Zolpidem. Depending on the pharmacy and your coverage, you could pay anywhere from $8.30-$58 per month. If you’re paying cash without insurance, each pill can cost about $21.64. 

Ambien Side Effects

Like Dayvigo, side effects of Ambien can include headaches and drowsiness. Additionally, you may experience:

  • Dizziness
  • Lightheadedness
  • Loss of coordination or balance
  • Congestion
  • Nausea
  • Dry mouth
  • Constipation
  • Diarrhea 
  • Confusion
  • Stomach ache
  • Euphoria
  • Muscle pain
  • Visual changes

More severe side effects can include memory loss or changes in behavior or mental state. These changes could look like suicidal ideation, depression, anxiety, or aggression. While these side effects are rare, you should contact your doctor immediately if they arise. 

Additionally, Ambien may contain lactose and can cause a more severe allergic reaction. If you experience shortness of breath, chest pains, or difficulty swallowing, stop taking Ambien immediately and call your doctor.

If you stop taking Ambien, you could experience withdrawal symptoms like muscle cramps, sweats, shaking, and seizures. Always consult your doctor for the best ways to stop taking any medication you’ve been prescribed. 

Ambien Warnings for Use

Before taking Ambien, make sure that you tell your healthcare provider if you’ve ever been depressed, suicidal, mentally ill, experienced addiction, breathing problems, sleep apnea, liver or kidney disease. It may not be safe to take Ambien if you’re pregnant or breastfeeding, so consult your doctor before use. 

You always want to make sure you have 7-8 hours of sleep before you need to be active when taking Ambien. The sedative can be stronger for elderly patients. Still, everyone should be sure to wait until fully awake before operating a vehicle, machinery, or any activity that requires alertness. 

Ambien Interactions

Taking Ambien with other drugs that make you sleepy can intensify the effects. You should talk to your doctor if you’re also using opioids, sleeping pills, muscle relaxers, anxiety medications, or anti-seizure medications. 

There are 434 drugs that interact with Zolpidem. Within those medications, the most frequently checked include a major interaction with Tramadol and moderate interactions with the following:

  • Ativan
  • Clonazepam
  • Cymbalta
  • Flexeril
  • Gabapentin
  • Klonopin
  • Lexapro
  • Lisinopril
  • Lyrica
  • Trazodone
  • Xanax
  • Zoloft

Ambien interacts with eight diseases, including major interactions with:

  • Alcohol intoxication
  • Depression
  • Drug dependence
  • Liver disease

Moderate interactions include:

  • Glaucoma
  • Renal dysfunction
  • Liver disease 
  • Respiratory depression

Which Insomnia Medication Should I Take?

Each medication has a different effect based on your individual body chemistry.  If you experience issues with substance dependency, Dayvigo and Ambien may not be right for you. Dayvigo in particular has a major interaction with alcohol and you should consult your healthcare provider before determining which medication is best for you.

Dayvigo and Ambien Frequently Asked Questions

Are Dayvigo and Ambien the same class of drug?

No. Dayvigo is an orexin receptor antagonist, whereas Ambien is a sedative or hypnotic. Dayvigo blocks the production of orexin to help you fall asleep, while Ambien works to alleviate chemical imbalances so that you can fall and stay asleep.

What’s better for insomnia? Dayvigo or Ambien?

Both Dayvigo and Ambien work to treat insomnia. The kind you take depends on your current health, your health history, and your doctor’s recommendation. 

Can Dayvigo cause depression? Can Ambien?

Both Dayvigo and Ambien can result in worsening depression or thoughts about self-harm. You should always talk to your doctor if you’re experiencing any changes in your mood or behavior.

Can I drive on Dayvigo or Ambien?

You should not drive if you’re drowsy or haven’t gotten at least 7-8 hours of sleep since taking Dayvigo or Ambien. Both drugs can act shortly after taking them, so you should only take them before bed and not before any other activity. Do not operate a vehicle or any machinery if you’re not fully alert. 

Can I drink alcohol when taking Dayvigo or Ambien?

Both Dayvigo and Ambien interact with alcohol, and you should consult your doctor before taking either drug if you drink. Drinking while taking Dayvigo can increase the possibility of side effects like dizziness, memory issues, and sleepiness throughout the day. If you drink alcohol while taking Ambien, you could experience confusion, dizziness, sleep apnea, or even overdose. 

Does it matter what time of day I take Dayvigo or Ambien?

You should only take Dayvigo or Ambien before bed when you have 7-8 hours before you need to be awake and active again. 

Start Your Insomnia Treatment Today with Healthcare Providers on Klarity 

Feeling drained from insomnia? Trying to find a healthcare provider who will listen to your needs and guide you to the right treatment can be difficult and stressful. Not to mention, waiting for appointments and follow-ups to receive your medication takes up time you don’t have. 

At Klarity, you’ll have access to affordable medical providers who can diagnose illnesses and prescribe medication—all within 48 hours. No more waiting weeks to be seen and inconvenient commutes. 

Take the first step to feeling reenergized and refreshed by completing a brief 2-minute self-evaluation. We’ll connect you with an insomnia provider in 48 hours or less who will create a plan of care tailored to you and your needs. 

Start today, and discuss your symptoms with a specialist who can help.

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