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Evekeo vs. Adderall: What’s the Difference & Which One Should I Take?


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Choosing the right ADHD medication can be daunting, especially with so many available choices. Though having a wide variety of available medications means more people can get treatment safely, finding the medication that works for you can quickly become complex—which is especially frustrating for someone already having difficulty concentrating. 

That’s why, in this article, we’ve broken down the similarities, differences, and risks of two stimulant drugs most often prescribed to treat ADHD so you can more easily find the medication that’s right for you. 

If you want to get in front of a licensed ADHD specialist within 48 hours to help diagnose and prescribe medication, Klarity can help!

What is Evekeo?

Evekeo is similar to Adderall in that it contains both amphetamine and dextroamphetamine. The difference is that Evekeo contains 50% of each drug, whereas Adderall contains 75% dextroamphetamine and 25% amphetamine. Evekeo, approved by the FDA in 2014, is a fast-acting, immediate release (IR) ADHD stimulant that works by targeting the neurotransmitters in the brain controlling behaviors like impulsivity and hyperactivity.

Forms and Dosages

Evekeo comes in 5 mg and 10 mg blue or gray scored tablets that can easily be broken into halves. Doses can be taken one to three times per day according to a doctor’s instructions. Adults typically start off with a 2.5 mg or 5 mg dose one to two times per day and increase the dosage as needed. 

Conditions Treated

Evekeo is primarily used to treat ADHD (attention-deficit hyperactivity disorder), some forms of narcolepsy, and in some cases, obesity. 


Because it hasn’t been on the market very long, you may be hard-pressed to find an insurance provider that covers Evekeo. Contact your insurance provider and ask them if they cover it or offer discounts for the medication. For out-of-pocket costs, you’re potentially looking at $400 to $450 for a one-month supply of Evekeo. Online coupons or savings offered by your ADHD physician may help bring this medication down to between $50 and $150.

Side Effects

Some of the side effects of Evekeo include but are not limited to: 

  • Palpitations 
  • Tachycardia 
  • Hypertension 
  • Overstimulation 
  • Restlessness 
  • Dizziness 
  • Sleeplessness 
  • Dyskinesia 
  • Dysphoria 
  • Tremor 
  • Headache 
  • Seizures
  • Visual disturbances 
  • Dry mouth 
  • Unpleasant taste 
  • Gastrointestinal disturbances 
  • Changes in weight 
  • Urticaria 
  • Impotence 
  • Changes in libido 
  • Frequent or prolonged erections 
  • Peripheral vasculopathy 
  • Including Raynaud’s phenomenon

Warnings and Drug Interactions

Speak with your healthcare provider before taking this medication if you have a history of heart or circulatory problems, drug abuse, or if you’ve taken an MAOI within the past two weeks. Stimulants can cause a dangerous increase in blood pressure and heart rate. They can also exacerbate issues in individuals experiencing a mental health crisis, including hallucinations and paranoia. 

What is Adderall?

Adderall is an ADHD medication with the same ingredients as Evekeo but contains a different ratio with a mixture of 75% dextroamphetamine and 25% amphetamine. Adderall is a central nervous system stimulant that works by targeting the neurotransmitters in the brain that control impulsivity, hyperactivity, and lack of focus.

Forms and Dosages

Adderall’s immediate-release (IR) tablets come in 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, and 30 mg. The tablets can be taken one to two times per day and should not be taken after 12 PM to avoid experiencing issues with restlessness and sleep.

Conditions Treated

This ADHD medication is approved by the FDA to treat ADHD (attention-deficit hyperactivity disorder) and sleeping disorders like narcolepsy.


If you’re approved to take Adderall, you can expect the medication to run nearly $8 per day out-of-pocket. If you have health insurance, you likely pay anywhere from $10-$30 for the generic form. For more information on pricing for Adderall or its longer-lasting Adderall XR formula, contact your health insurance provider. 

Side Effects

Adderall is a central nervous system stimulant, and with that comes a few side effects. Side effects of Adderall include but are not limited to:

  • Irregular heartbeat
  • Elevated heart rate
  • Increased blood pressure
  • Restlessness
  • Dry mouth
  • Diarrhea, constipation, nausea
  • Headache
  • Weight loss
  • Mood changes
  • Anxiety
  • Dizziness

Some of the lesser, rarer side effects include:

  • Seizures
  • Eyesight instability
  • Urinary tract infection
  • Nausea
  • Fever
  • Stroke
  • Heart attack

Warnings and Drug Interactions

Adderall has several drug interactions you should be aware of. Speak with an ADHD physician if you take any of the following medications:

  • SSRI & SNRI drugs
  • Blood pressure medication
  • Acid reflux medication
  • Blood thinners
  • Cold or allergy medication
  • Opioids
  • Seizure medication

If you experience hives or any sign of an allergic reaction when taking Adderall, get emergency medical assistance. Call a healthcare provider immediately if you experience any of the following:

  • Heart issues
  • Signs of psychosis
  • Circulatory issues
  • Seizures
  • Muscle twitches and tics
  • Vision changes 

Adderall is a controlled substance that can induce withdrawal if stopped immediately. Do not stop taking Adderall unless instructed by a physician. 

Is Evekeo or Adderall Better for Your ADHD?

Both Evekeo and Adderall are effective medications for adults with ADHD. These medications are similar in chemical components but different in ratio. Because these medications contain the same ingredients, it’s best to speak with an ADHD physician who can effectively explain whether Evekeo or Adderall will be better for your specific condition. Also, remember that budget may be a factor in this comparison—Evekeo is not in generic form and is likely more expensive than Adderall.

How Klarity Helps You Find the Best ADHD Medication

Whether you’re considering Evekeo or Adderall as your primary ADHD medication, Klarity can connect you with a licensed medical provider who will thoroughly evaluate your symptoms and help you choose the treatment that works for you (if applicable). Take a free self-evaluation, or book an appointment with an ADHD specialist today!

Start today, and discuss your symptoms with a specialist who can help.

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