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Inderal vs Zebeta: Which Beta-Blocker Should I Take for Anxiety?


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Sometimes the medications you’ve been taking to manage your anxiety symptoms stop working, or you’re no longer able to take them. Or, perhaps, you’re newly exploring different treatment options. Trying to figure out your next steps while living with anxiety can be difficult, but you’re not alone. 

In this article, we’ll explore how beta-blockers Inderal and Zebeta can treat physical symptoms of anxiety so that you can have an informed discussion with your care provider when pursuing treatment. 

At Klarity, we provide access to affordable and accessible online anxiety treatment. Just take this brief 2-minute survey, and we’ll connect you with a licensed provider within 48 hours. 

Zebeta and Inderal are Both Beta-Blockers. What Does That Mean?

Zebeta and Inderal are both in the same drug class known as beta-blockers or beta-adrenergic blocking agents. 

What are Beta-Blockers?

Your body uses chemical signals to make certain functions happen. Receptors on your individual cells are sites where neurotransmitters connect to trigger a response or a reaction. If you’re stressed, for example, epinephrine is a neurotransmitter that binds with your receptors to send your body into fight or flight. 

Beta-blockers are medications that stop your body’s response to epinephrine or adrenaline. These medications are primarily used to treat cardiovascular issues like high blood pressure and circulatory problems and to combat heart failure. However, beta-blockers can also be prescribed off-label to treat other conditions. 

How Do Beta-Blockers Work?

Beta-blockers stop the activity of the hormone epinephrine, also known as adrenaline, so your heart rate slows down, and your blood pressure can return to normal. These medications bind to your receptors and act as a buffer preventing epinephrine from attaching to your receptors and activating your body’s stress response. 

While beta-blockers can help with heart or circulatory issues, they can also be effective when treating the physical symptoms of performance or social anxiety.

Zebeta and Inderal Can Treat Physical Symptoms of Anxiety

While Zebeta and Inderal are not FDA-approved to treat anxiety, they can be prescribed off-label to alleviate some of the physical symptoms of anxiety. 

What Else Does Zebeta Treat?

Zebeta (also known as Bisoprolol) is primarily used to treat hypertension and heart failure. This medication works by blocking epinephrine activity so that your heart experiences less strain, your heart rate normalizes, and your blood pressure becomes stable. 

Zebeta can also be prescribed off-label, meaning that while it’s only FDA-approved for cardiovascular issues, it can treat other conditions.

Off-label Uses for Zebeta  

Zebeta doesn’t address the psychological aspects of navigating anxiety, but it can be prescribed to help alleviate the physical symptoms of anxiety, like a racing heart. Because Zebeta opens your blood vessels, it improves circulation and calms you. 

What Else Does Inderal Treat?

Inderal (Propranolol) also treats cardiovascular issues like hypertension and heart attacks. Additionally, this medication can be prescribed for chest pain and certain heart rhythm disorders. Like Zebeta, Inderal has off-label uses for the physical symptoms of anxiety.

Off-label Uses for Inderal 

Inderal can be used off-label to treat the physical symptoms of anxiety, including a racing heart, sweaty palms, or trembling. Because spikes in adrenaline can be related to stress, beta blockers slow your body’s response, giving you the space to focus on regulating your psychological symptoms.

What is Inderal? 

Inderal (Propranolol) is a beta blocker typically prescribed for cardiovascular issues. However, because it blocks adrenaline and can lower your heart rate, it is also used off-label to treat physical symptoms of anxiety.

Inderal has several possible side effects and is available in various forms and doses.

Common Inderal Doses and Forms

You can find Inderal in a capsule, tablet, or liquid form. Because this beta blocker can treat several conditions, your dosage will vary based on your care provider’s recommendation. The typical dosage ranges from 10 mg to 160 mg, but for anxiety, you’ll likely start at 10 mg to see how you respond and work your way up if necessary. 

Common Inderal Side Effects

Common side effects of Inderal include the following:

  • Dizziness or lightheadedness
  • Nausea or vomiting
  • Diarrhea or constipation
  • Stomach cramping
  • Insomnia
  • Sore throat
  • Runny nose or congestion

Contact your healthcare provider immediately if you experience these more severe side effects:

  • Slow or uneven heartbeats
  • Difficulty breathing
  • Weakness or loss of coordination
  • Vision problems
  • Coldness in your hands or feet
  • Depression
  • Confusion or hallucinations
  • Swelling
  • Rapid weight gain
  • Low blood sugar

Common Inderal Drug Interactions

Inderal interacts with 533 drugs, with 42 major interactions, 444 moderate interactions, and 47 minor interactions. Of the most frequently checked medications, Inderal has moderate interactions with the following:

  • Clonazepam
  • Cymbalta
  • Flexeril
  • Klonopin
  • Prozac
  • Seroquel
  • Trazodone
  • Xanax
  • Zoloft

You should not suddenly stop taking Inderal because it can increase the risk of heart failure. Speak with your healthcare provider to learn how to discontinue using this medication safely. 

How Much Does Inderal Cost?

How much you pay for Inderal depends on your dosage, insurance coverage, and the pharmacy you use to source your medication. You can typically expect to pay anywhere from $3.68 to $26.55. 

What is Zebeta?   

Zebeta (Bisoprolol) is a beta blocker that’s FDA-approved to treat hypertension and congenital heart failure. That said, it’s also prescribed off-label to alleviate the physical symptoms of anxiety like a racing heart, sweating, or trembling.

It’s important to follow the instructions of your care provider to ensure that you’re taking the right dose to treat your symptoms. 

Common Zebeta Doses and Forms

Like Inderal, Zebeta is prescribed as a tablet in different dosages depending on your condition and the advice of your healthcare provider. You can expect to take anywhere from 10 mg to 20 mg a day to treat the physical symptoms of anxiety. 

Common Zebeta Side Effects

The most common side effects of Zebeta include:

  • Headaches
  • Tiredness
  • Sleep problems
  • Joint pain
  • Swelling
  • Cold symptoms like a runny or stuffy nose and a sore throat

More serious side effects include the following:

  • Lightheadedness
  • Dizziness
  • Shortness of breath
  • Rapid weight gain
  • Slow heart rate
  • Eye pain or vision problems
  • Trouble breathing
  • Chest tightness
  • Pounding heartbeats
  • Numbness or tingling in your hands or feet

You should not stop taking Zebeta suddenly, as it can increase the risk of a heart attack. Talk with your care provider about how to taper off this medication safely.

Common Zebeta Drug Interactions

Zebeta interacts with 451 drugs, with 25 major interactions, 388 moderate interactions, and 28 minor interactions. When cross-referenced with the most frequently checked medications, Zebeta has moderate interactions with Lasix, Norvasc, Trazodone, and Xanax. 

How Much Does Zebeta Cost?

Zebeta typically costs anywhere from $3.78 to $32.94. However, that price may vary depending on your dosage, insurance coverage, and the pharmacy you use. 

Do I Need A Prescription for Zebeta or Inderal?

Yes, you will need a prescription for Zebeta and Inderal. Sourcing your medications from a trusted pharmacy is essential to your safety, as selling beta-blockers without requiring a prescription is illegal. If you purchase drugs without a prescription, there’s no way to ensure the medication doesn’t include other harmful substances. 

Beta Blocker Warnings For Use

Certain beta-blockers may not be right for you, especially if you’re pregnant or breastfeeding.

Pregnancy and Breastfeeding on Beta-Blockers

Zebeta and Inderal should only be used if no other options are available while pregnant or breastfeeding. While it may not affect all babies, some can experience a slowed heart rate or low blood sugar. 

Frequently Asked Questions

Are Inderal, Zebeta, and other Beta-Blockers the same drug?

While Inderal and Zebeta are in the same class of drugs – beta-blockers – they have different doses, forms, and side effects. 

What’s better for anxiety, Inderal or Zebeta?

Both Inderal and Zebeta can treat the physical symptoms of anxiety. The one that’s best for you will depend on your current symptoms and the recommendation of your care provider. 

Can I drink alcohol on Inderal or Zebeta?

Alcohol can impact the effectiveness of Inderal and Zebeta and increase the possibility of adverse side effects, so you should talk with your care provider before drinking and taking either of these beta-blockers. 

Does it matter what time of day I take Inderal or Zebeta?

Zebeta and Inderal can make you tired or drowsy, so it’s best to take your initial doses when you don’t have to operate a vehicle or heavy machinery. Once you’ve identified how your body reacts to the medication, you can ask your care provider about taking it at different times that best suit your schedule. 

How Klarity Helps You Access Anxiety Treatment

Accessing anxiety treatment can be overwhelming when you have to take time off work, make inconvenient commutes, and navigate long wait times. 

The compassionate anxiety-trained providers on Klarity know that your time is valuable, and they’ll ensure that you get the treatment you need. Our platform gives you fast, affordable access so that you can get the diagnosis and treatment you need right from the comfort of your home. 
We’ll connect you with a care provider in your state within 48 hours of taking our brief assessment. Take the survey today and start your journey toward living symptom-free.


Sanjai Sinha. “Inderal”


Mayo Clinic Staff. “Beta blockers” Mayo Clinic

“Bisoprolol (Zebeta) For Anxiety: Can Bisoprolol Help With Anxiety Symptoms?”

Scott McDougall. “What Is Propranolol? Propranolol For Anxiety & Other Conditions” The Independent Pharmacy

“Inderal Interactions”,inderal.html

“Generic Inderal” GoodRx

“Zebeta” RxList

“Zebeta Interactions”,zebeta.html

“Zebeta Prices, Coupons, and Patient Assistance Programs”

“Generic Zebeta” GoodRx

“Propranolol Pregnancy and Breastfeeding Warnings”

“Compare Bisoprolol vs. Propranolol” Iodine

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